寄生虫水孔蛋白研究进展

doi:10.11843/j.issn.0366-6964.2015.05.002

Abstract

Abstract:

Aquaporin （AQP） is one of integral membrane proteins from a family of major intrinsic proteins （MIP）.Recent studies revealed that aquaporins in parasites involve in the regulation of osmotic homeostasis，transport process of nutrition，metabolites and anti-parasite drugs，which indicated that the protein could serve as novel vaccine candidate or potential anti-parasite drug’s targets.Learning about the functions and structures of aquaporins in parasites will be of great significance in prevention and treatment of parasitic diseases.This article reviews the functions and structural characteristics of aquaporins in parasites，in order to provide references for the study of the biological agents against parasite diseases.

CLC Number:

S852.7

CUI Jian-min，ZHANG Nian-zhang，FU Bao-quan. Research Advances in Aquaporin of Parasites[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(5): 689-695.

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References

［1］隋海心，任罡.水分子通道蛋白的结构与功能［J］.化学进展，2004，16（2）：145-152.
SUI H X，REN G.Structure and mechanism of water channels［J］. Progress in Chemistry，2004，16（2）：145-152.（in Chinese）
［2］GOMES D，AGASSE A，THIÉBAUD P，et al.Aquaporins are multifunctional water and solute transporters highly divergent in living organisms［J］.Biochim Biophys Acta，2009，1788（6）：1213-1228.
［3］BEITZ E.Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa［J］.Chem Med Chem，2006，1（6）：587-592.
［4］CAMPBELL E M，BALL A，HOPPLER S，et al.Invertebrate aquaporins：a review［J］.J Comp Physiol B，2008，178（8）：935-955.
［5］BEITZ E.Aquaporins from pathogenic protozoan parasites：structure，function and potential for chemotherapy［J］.Biol Cell，2005，97（6）：373-383.
［6］GENA P，PELLEGRINI-CALACE M，BIASCO A，et al.Aquaporin membrane channels：biophysics，classification，functions，and possible biotechnological applications［J］.Food Biophys，2011，6（2）：241-249.
［7］MAGNI F，SARTO C，TICOZZI D，et al.Proteomic knowledge of human aquaporins［J］.Proteomics，2006，6（20）：5637-5649.
［8］YASUI M.Molecular mechanisms and drug development in aquaporin water channel diseases：structure and function of aquaporins［J］.J Pharmacol Sci，2004，96（3）：260-263.
［9］HUBER V J，TSUJITA M，NAKADA T.Aquaporins in drug discovery and pharmacotherapy［J］.Mol Aspects Med，2012，33（5-6）：691-703.
［10］SONG J，MAK E，WU B，et al.Parasite aquaporins：current development in drug facilitation and resistance［J］.Biochim Biophys Acta，2014，1840（5）：1566-1573.
［11］HANSEN M，KUN J F J，SCHULTZ J E，et al.A single，bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites［J］.J Biol Chem，2002，277（7）：4874-4882.
［12］NEWBY Z E R，O’CONNELL J 3rd，ROBLES-COLMENARES Y， et al.Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum ［J］.Nat Struct Mol Biol，2008，15（6）：619-625.
［13］BEITZ E R，PAVLOVIC-DJURANOVIC S，YASUI M，et al.Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis［J］.Proc Natl Acad Sci U S A，2004，101（5）：1153-1158.
［14］HEDFALK K，PETTERSSON N，OBERG F，et al.Production，characterization and crystallization of the Plasmodium falciparum aquaporin［J］.Protein Expr Purif，2008，59（1）：69-78.
［15］BAHAMONTES-ROSA N，WU B，BEITZ E，et al.Limited genetic diversity of the Plasmodium falciparum aquaglyceroporin gene［J］.Mol Biochem Parasitol，2007，156（2）：255-257.
［16］PAVLOVIC-DJURANOVIC S，KUN J F J，SCHULTZ J E，et al.Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation［J］.Biochim Biophys Acta，2006，1758（8）：1012-1017.
［17］PROMENEUR D，LIU Y J，MACIEL J，et al.Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei ［J］.Proc Natl Acad Sci USA，2007，104（7）：2211-2216.
［18］PAVLOVIC-DJURANOVIC S，SCHULTZ J E，BEITZ E.A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins［J］.FEBS Lett，2003，555（3）：500-504.
［19］UZCATEGUI N L，SZALLIES A，PAVLOVIC-DJURANOVIC S，et al.Cloning，heterologous expression，and characterization of three aquaglyceroporins from Trypanosoma brucei ［J］.J Biol Chem，2004，279（41）：42669-42676.
［20］UZCÁTEGUI N L，FIGARELLA K，BASSARAK B，et al.Trypanosoma brucei aquaglyceroporins facilitate the uptake of Arsenite and Antimonite in a pH dependent way［J］.Cell Physiol Biochem，2013，32（4）：880-888.
［21］MUNDAY J C，EZE A A，BAKER N，et al.Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs［J］.J Antimicrob Chemother，2014，69（3）：651-663.
［22］GRAF F E，LUDIN P，WENZLER T，et al.Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol［J］.PloS Negl Trop Dis，2013，7（10）：e2475.
［23］BASSARAK B，UZCÁTEGUI N L，SCHÖNFELD C，et al.Functional characterization of three aquaglyceroporins from Trypanosoma brucei in osmoregulation and glycerol transport［J］.Cell Physiol Biochem，2011，27（3-4）：411-420.
［24］FIGARELLA K，UZCATEGUI N L，ZHOU Y，et al.Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1：possible role in volume regulation and osmotaxis［J］.Mol Microbiol，2007，65（4）：1006-1017.
［25］UZCATEGUI N L，ZHOU Y，FIGARELLA K，et al.Alteration in glycerol and metalloid permeability by a single mutation in the extracellular C-loop of Leishmania major aquaglyceroporin LmAQP1［J］.Mol Microbiol，2008，70（6）：1477-1486.
［26］MUKHOPADHYAY R，MANDAL G，ATLURI V S R，et al.The role of alanine 163 in solute permeability of Leishmania major aquaglyceroporin LmAQP1［J］.Mol Biochem Parasitol，2011，175（1）：83-90.
［27］FAGHIRI Z，SKELLY P J.The role of tegumental aquaporin from the human parasitic worm，Schistosoma mansoni，in osmoregulation and drug uptake［J］.FASEB J，2009，23（8）：2780-2789.
［28］FAGHIRI Z，CAMARGO S M R，HUGGEL K，et al.The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ：The surface aquaporin SmAQP is a lactate transpoter［J］. PloS One，2010，5（5）：e10451.
［29］FIGUEIREDO B C P，DE ASSIS N R G，DE MORAIS S B，et al.Immunological characterization of a chimeric form of Schistosoma mansoni aquaporin in the murine model［J］.Parasitology，2014，141（10）：1277-1288.
［30］GEADKAEW A，VON BÜLOW J，BEITZ E，et al.Functional analysis of novel aquaporins from Fasciola gigantica ［J］.Mol Biochem Parasitol，2011，175（2）：144-153.
［31］SONG J，HE Q F.Bioinformatics analysis of the structure and linear B-cell epitopes of aquaporin-3 from Schistosoma japonicum ［J］.Asian Pac J Trop Med，2012，5（2）：107-109.
［32］MAH A K，ARMSTRONG K R，CHEW D S，et al.Transcriptional regulation of AQP-8，a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system，by the POU homeobox transcription factor CEH-6［J］.J Biol Chem，2007，282（38）：28074-28086.
［33］HUANG C G，LAMITINA T，AGRE P，et al.Functional analysis of the aquaporin gene family in Caenorhabditis elegans ［J］.Am J Physiol Cell Physiol，2007，292（5）：1867-1873.
［34］MANDAL G，MUKHOPADHYAY R.The role of aquaporins in pathogenic protozoan parasites：putative target for chemotherapy［J］.J Med Res Sci，2011，1（2）：29-47.
［35］LEE S J，MURPHY C T，KENYON C.Glucose shortens the life span of Caenorhabditis elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression［J］.Cell Metab，2009，10（5）：379-391.
［36］KUWAHARA M，ISHIBASHI K，GU Y，et al.A water channel of the nematode C.elegans and its implications for channel selectivity of MIP proteins［J］.Am J Physiol，1998，275（6 Pt 1）：1459-1464.
［37］BÜRGLIN T R，RUVKUN G.Regulation of ectodermal and excretory function by the C.elegans POU homeobox gene ceh-6［J］.Development，2001，128（5）：779-790.
［38］KUWAHARA M，ASAI T，SATO K，et al.Functional characterization of a water channel of the nematode Caenorhabditis elegans ［J］.Biochim Biophys Acta，2000，1517（1）：107-112.
［39］LOUKAS A，HUNT P，MAIZELS R M.Cloning and expression of an aquaporin-like gene from a parasitic nematode［J］.Mol Biochem Parasitol，1999，99（2）：287-293.
［40］HARA-CHIKUMA M，VERKMAN A S.Physiological roles of glycerol-transporting aquaporins：the aquaglycerporins［J］.Cell Mol Life Sci，2006，63（12）：1386-1392.
［41］CUI J，WANG Z Q，XU B L.The epidemiology of human trichinellosis in China during 2004-2009［J］.Acta Trop，2011，118（1）：1-5.

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Research Advances in Aquaporin of Parasites

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